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KMID : 1161420200230090998
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Journal of Medicinal Food
2020 Volume.23 No. 9 p.998 ~ p.1005
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Therapeutic Potential of Bauhinia forficata Link in Dental Biofilm Treatment
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Ferreira-Filho Julio Cesar C.
Marre Andressa Temperini de Oliveira
Almeida Juliana Soares de Sa
Lobo Leandro de Araujo
Farah Adriana
Romanos Maria Teresa Villela
Maia Lucianne Cople
Valenca Ana Maria Gondim
Fonseca-Goncalves Andrea
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Abstract
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The oral cytotoxicity, antimicrobial and anti-demineralizing effects of a tincture from Bauhinia forficata Link tincture (BFLT) were evaluated in vitro and ex vivo. Susceptibility tests (minimum inhibitory and microbicidal concentrations-MIC and time-kill assay-MMC) were performed against planktonic oral microorganisms. The contents of phenolic compounds were investigated. Cytotoxic potential was evaluated on oral fibroblasts after 1?5?min exposure to BFLT. Blocks of sound bovine enamel (N?=?60) were inoculated with a saliva pool and sustained in a multiple plaque growth system for 48?h to form a biofilm. Biofilm blocks were randomly divided into groups-G (n?=?10): G1-Baseline (48?h maturation biofilm), G2-BFLT 23.2?mg/mL, G3-Ethanol 81.20?g/mL, G4-Chlorhexidine 0.12%, G5-Growth control, and G6-Blank control. Treatments (50?μL/1?min) were performed once a day for a week. Streptococcus spp. (S) and total microorganism (TM) counts were expressed as Log10 CFU/mL. Biofilm height was evaluated by confocal microscopy analyses (CMA). Final surface hardness was assessed and percentage of microhardness loss (% MHL) was calculated. Results were significant when P?
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KEYWORD
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Bauhinia forficata Link, dental plaque, microbiology, microhardness, phytotherapy, tooth
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